Citation: Meng-Hua Wang, Li Li, Tao Jiang, Xue-Wei Wang, Bin-Da Sun, Bo Song, Qiu-Bo Zhang, Hong-Mei Jia, Gang Ding, Zhong-Mei Zou. Stereochemical determination of tetrahydropyran-substituted xanthones from fungus Chaetomium murorum[J]. Chinese Chemical Letters, ;2015, 26(12): 1507-1510. doi: 10.1016/j.cclet.2015.10.025 shu

Stereochemical determination of tetrahydropyran-substituted xanthones from fungus Chaetomium murorum

Meng-Hua Wang ^a ,
Li Li ^b ,
Tao Jiang ^a ,
Xue-Wei Wang ^c ,
Bin-Da Sun ^c ,
Bo Song ^a ,
Qiu-Bo Zhang ^a ,
Hong-Mei Jia ^a ,
Gang Ding ^a,b,, ,
Zhong-Mei Zou ^a,,

1.
a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China;
2.
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China;
3.
c State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China

Corresponding author: Gang Ding, Zhong-Mei Zou,
Received Date: 17 July 2015
Available Online: 13 October 2015

Chaetoxanthone D (1), a new tetrahydropyran-substituted xanthone originated from polyketide pathway, together with the four known natural products chaetoxanthone C (2), alternariol methyl ether (3), alternariol (4) and 2,5-dimethyl-7-hydroxychromone (5) was isolated from a strain of Chaetomium murorum. The structures of these compounds were elucidated based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were determined by using quantum chemical electronic circular dichroism (ECD) calculations.
- Chaetomium murorum
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