Citation: Gao-Lei Wang, Xi Chen, Ya-Ning Chang, Dan Du, Zhong Li, Xiao-Yong Xu. Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation[J]. Chinese Chemical Letters, ;2015, 26(12): 1502-1506. doi: 10.1016/j.cclet.2015.10.024 shu

Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation

Gao-Lei Wang ^a ,
Xi Chen ^a ,
Ya-Ning Chang ^a ,
Dan Du ^a ,
Zhong Li ^a,b ,
Xiao-Yong Xu ^a,b,,

1.
a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
2.
b Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

Corresponding author: Xiao-Yong Xu,
Received Date: 13 July 2015
Available Online: 12 October 2015

To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3- benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 6k and 6p displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.
- 1,2,3-Benzotriazin-4-one
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