Citation: Wen-Qiang Qu, Yi-Ran Xia, Li-Juan Jiang, Li-Wei Zhang, Zhao-Sheng Hou. Synthesis and characterization of a new biodegradable polyurethanes with good mechanical properties[J]. Chinese Chemical Letters, ;2016, 27(01): 135-138. doi: 10.1016/j.cclet.2015.07.018 shu

Synthesis and characterization of a new biodegradable polyurethanes with good mechanical properties

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a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan 250014, China;
2.
b Shandong Academy of Pharmaceutical Sciences, Shandong Provincial Key Laboratory of Biomedical Polymer, Jinan 250101, China;
c Shandong Success Pharmaceutical Technology Co.
c Shandong Success Pharmaceutical Technology Co., Ltd., Jinan 250101, China

Corresponding author: Zhao-Sheng Hou,
Received Date: 10 June 2015
Available Online: 3 July 2015
Fund Project: Jinan City Universities and Institutes Independent Innovation Planning Project, China(No. 201402044). (No. ZR2013EMM004)

In the paper, a new biodegradable polyurethane(PU, PU-I) was prepared:the prepolymer was synthesized via bulk ring-opening polymerization with poly(ethylene glycol)(M_n=600)(PEG600) as an initiator and _L-lactide(_L-LA), e-caprolactone(CL) as monomers, and the prepolymer was chain-extended with an isocyanate-terminated urethane triblock(macrodiisocyanate) to prepare the PU. The macrodiisocyanate, prepolymer and PUs were characterized by ¹H NMR, ¹³C NMR, FT-IR, high resolution mass spectrometry(HR-MS), gel permeation chromatography(GPC), thermo gravimetric analysis(TGA), and differential scanning calorimetry(DSC). The corresponding PU films showed excellent mechanical properties with a tensile strength of 27.5 MPa and an elongation at break of 996%, and also maintained mechanical properties in physiological saline at 37℃ for more than three weeks, which appeared to be more suitable for biomedical applications.
- Ring-opening polymerization,
- Biodegradable,
- Polyurethanes,
- Mechanical property
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