Citation: Aysegul Kutluay, Mehmet Aslanoglu. Quantification of methyldopa in pharmaceuticals using a glassy carbon electrode modified with carbon nanotubes[J]. Chinese Chemical Letters, ;2016, 27(01): 91-95. doi: 10.1016/j.cclet.2015.04.038 shu

Quantification of methyldopa in pharmaceuticals using a glassy carbon electrode modified with carbon nanotubes

Aysegul Kutluay ,
Mehmet Aslanoglu ^,

1.
Department of Chemistry, University of Harran, Sanliurfa 63510, Turkey

Corresponding author: Mehmet Aslanoglu,
Received Date: 4 January 2015
Available Online: 1 April 2015

The quantification of methyldopa in pharmaceuticals has been carried out using a glassy carbon electrode(GCE) modified with multi-walled carbon nanotubes(MWCNTs). Methyldopa exhibited a quasi-reversible response with a peak potential separation of 473 mV on a bare GCE. However, the cyclic voltammetric behaviour of methyldopa was improved with the increase of the amount of MWCNTs. It was also shown that the electrocatalytic activity of the electrode towards the response of methyldopa was higher with larger amount of film on the surface. The results showed that the peak current was proportional to the concentration of methyldopa with a linear dynamic range of 0.005-0.388μmol/L and a detection limit of 1.0 nmol/L was obtained using square wave voltammetry. The experimental data showed that the detection limit of methyldopa and peak separation from interfering compounds such as ascorbic acid(AA) and uric acid(UA) were improved using the proposed procedure. The method was successfully applied for the determination of methyldopa in pharmaceuticals.
- Methyldopa,
- Carbon nanotubes,
- Ascorbic acid,
- Uric acid
1. [1]
  [1] P.R.S. Ribeiro, J.A. Gomes Neto, L. Pezza, H.R. Pezza, Flow-injection spectrophotometric determination of methyldopa in pharmaceutical formulations, Talanta 67(2005) 240-244.
2. [2]
  [2] E.A. Gadkariem, K.E.E. Ibrahim, N.A.A. Kamil, M.E.M. Haga, H.A. El-Obeid, A new spectrophotometric method for the determination of methyldopa, Saudi Pharm. J. 17(2009) 289-293.
3. [3]
  [3] M. Tubino, D.C.D.V. Batista, J.A.R. Rodrigues, Kinetic method for the determination of alpha-methyldopa in pharmaceutical preparations:analytical procedure and reaction mechanism considerations, Anal. Lett. 39(2006) 327-339.
4. [4]
  [4] S. Li, H. Wu, Y. Yu, et al., Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm, Talanta 81(2010) 805-812.
5. [5]
  [5] C. Muzzi, E. Bertocci, L. Terzuoli, et al., Simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and alpha-methyldopa by HPLC, Biomed. Pharmacother. 62(2008) 253-258.
6. [6]
  [6] T.S. James, C.L.O. Hoo, D.M. William, Determination of methyldopa in pharmaceutical dosage forms and biological fluids based on oxidation at the tubular carbon electrode, J. Pharm. Sci. 63(2006) 954-955.
7. [7]
  [7] L.K. Abdulrahman, A.M. Al-Abachi, M.H. Al-Qaissy, Flow injection-spectrophotometeric determination of some catecholamine drugs in pharmaceutical preparations via oxidative coupling reaction with p-toluidine and sodium periodate, Anal. Chim. Acta 538(2005) 331-335.
8. [8]
  [8] Z. Talebpour, S. Haghgoo, M. Shamsipur, ¹H nuclear magnetic resonance spectroscopy analysis for simultaneous determination of levodopa, carbidopa and methyldopa in human serum and pharmaceutical formulations, Anal. Chim. Acta 506(2004) 97-104.
9. [9]
  [9] S.K. Moccelini, A.C. Franzoi, I.C. Vieira, J. Dupont, C.W. Scheeren, A novel support for laccase immobilization:cellulose acetate modified with ionic liquid and application in biosensor for methyldopa detection, Biosens. Bioelectron. 26(2011) 3549-3554.
10. [10]
  [10] M.B. Gholivand, M. Amiri, Preparation of polypyrrole/nuclear fast red films on gold electrode and its application on the electrocatalytic determination of methyl-dopa and ascorbic acid, Electroanalysis 21(2009) 2461-2467.
11. [11]
  [11] S. Shahrokhian, S. Rastgar, Electrodeposition of Pt-Ru nanoparticles on multiwalled carbon nanotubes:application in sensitive voltammetric determination of methyldopa, Electrochim. Acta 58(2011) 125-133.
12. [12]
  [12] A. Kutluay, M. Aslanoglu, Nickel nanoparticles functionalized multi-walled carbon nanotubes at platinum electrodes for the detection of bromhexine, Sens. Actuators B 192(2014) 720-724.
13. [13]
  [13] Xi. Yang, B. Feng, P. Yang, Y. Ding, Y. Chen, J. Fei, Electrochemical determination of toxic ractopamine at an ordered mesoporous carbon modified electrode, Food Chem. 145(2014) 619-624.
14. [14]
  [14] H.R. Zare, F. Chatraei, Preparation and electrochemical characteristics of electrodeposited acetaminophen on ruthenium oxide nanoparticles and its role as a sensor for simultaneous determination of ascorbic acid, dopamine and N-acetylL-cysteine, Sens. Actuators B 160(2011) 1450-1457.
15. [15]
  [15] A. Salimi, S. Lashgari, A. Noorbakhsh, Carbon nanotubes-ionic liquid and chloropromazine modified electrode for determination of NADH and fabrication of ethanol biosensor, Electroanalysis 22(2010) 1707-1716.
16. [16]
  [16] X.H. Liu, L. Li, X.P. Zhao, X.Q. Lu, Electrochemical behavior of rutin on a multiwalled carbon nanotube and ionic liquid composite film modified electrode, Colloids Surf. B 81(2010) 344-349.
17. [17]
  [17] A. Kutluay, M. Aslanoglu, Selective detection of albuterol in the presence of uric acid using a glassy carbon electrode modified with multi-walled carbon nanotubes and poly(pivalic acid), Sens. Actuators B 177(2013) 703-709.
18. [18]
  [18] A. Babaei, M. Zendehdel, B. Khalilzadeh, A. Taheri, Simultaneous determination of tryptophan, uric acid and ascorbic acid at iron(ⅡI) doped zeolite modified carbon paste electrode, Colloids Surf. B 66(2006) 226-232.
19. [19]
  [19] H. Beitollahi, I. Sheikhshoaie, Electrocatalytic and simultaneous determination of isoproterenol, uric acid and folic acid at molybdenum(VI) complex-carbon nanotube paste electrode, Electrochim. Acta 56(2011) 10259-10263.
20. [20]
  [20] R. Hosseinzadeh, R.E. Sabzi, K. Ghasemlu, Effect of cetyltrimethyl ammonium bromide(CTAB) in determination of dopamine and ascorbic acid using carbon paste electrode modified with tin hexacyanoferrate, Colloids Surf. B 68(2009) 213-217.
21. [21]
  [21] J.B. Raoof, R. Ojani, H. Beitollahi, L-Cysteine voltammetry at a carbon paste electrode bulk-modified with ferrocenedicarboxylic acid, Electroanalysis 19(2007) 1822-1830.
22. [22]
  [22] H.F. Zhang, Z.C. Meng, Q. Wang, J.B. Zheng, A novel glucose biosensor based on direct electrochemistry of glucose oxidase incorporated in biomediated gold nanoparticles-carbon nanotubes composite film, Sens. Actuators B 158(2011) 23-27.
23. [23]
  [23] H.R. Zare, N. Nasirizadeh, H. Ajamain, A. Sahragard, Preparation, electrochemical behavior and electrocatalytic activity of chlorogenic acid multi-wall carbon nanotubes as a hydroxylamine sensor, Mater. Sci. Eng. C 31(2011) 975-982.
24. [24]
  [24] A. Kutluay, M. Aslanoglu, Multi-walled carbon nanotubes/electro-copolymerized cobalt nanoparticles-poly(pivalic acid) composite film coated glassy carbon electrode for the determination of methimazole, Sens. Actuators B 171-172(2012) 1216-1221.
25. [25]
  [25] M.M. Rahman, M.J.A. Shiddiky, M.D.A. Rahman, Y.D. Shim, A lactate biosensor based on lactate dehydrogenase/nictotinamide adenine dinucleotide(oxidized form) immobilized on a conducting polymer/multiwall carbon nanotube composite film, Anal. Biochem. 384(2009) 159-165.
26. [26]
  [26] M. Keyvanfard, R. Shakeri, H. Karimi-Maleh, K. Alizad, Highly selective and sensitive voltammetric sensor based on modified multiwall carbon nanotube paste electrode for simultaneous determination of ascorbic acid, acetaminophen and tryptophan, Mater. Sci. Eng. C 33(2013) 811-816.
27. [27]
  [27] M. Keyvanfard, M. Ahmadi, F. Karimi, K. Alizad, Voltammetric determination of cysteamine at multiwalled carbon nanotubes paste electrode in the presence of isoproterenol as a mediator, Chin. Chem. Lett. 25(2014) 1244-1246.
28. [28]
  [28] T.L. Lu, Y.C. Tsai, Sensitive electrochemical determination of acetaminophen in pharmaceutical formulations at multiwalled carbon nanotube-alumina-coated silica nanocomposite modified electrode, Sens. Actuators B 153(2011) 439-444.
29. [29]
  [29] M.C. Henstridge, E.J.F. Dickinson, M. Aslanoglu, C. Batchelor-McAuley, R.G. Compton, Voltammetric selectivity conferred by the modification of electrodes using conductive porous layers or films:The oxidation of dopamine on glassy carbon electrodes modified with multiwalled carbon nanotubes, Sens. Actuators B 145(2010) 417-427.
30. [30]
  [30] United States Pharmacopeia National Formulary 23rd Revision, US Pharmacopeial Convention, Rockville, MD, 1995.
31. [31]
  [31] I. da Cruz Vieira, O. Fatibello-Filho, Spectrophotometric determination of methyldopa and dopamine in pharmaceutical formulations using a crude extract of sweet potato root(Ipomoea batatas(L.) Lam.) as enzymatic source, Talanta 46(1998) 559-564.
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