Citation: Rui Tao, Xue-Jiao Yin, Ke-Hu Wang, Yu-Zhuo Niu, Ya-Lin Wang, Dan-Feng Huang, Ying-Peng Su, Jin-Xian Wang, Yu-Lai Hu, Ying Fu, Zheng-Yin Du. Solvent free synthesis of trifluoromethyl tertiary alcohols by cross Aldol reaction[J]. Chinese Chemical Letters, ;2015, 26(8): 1046-1049. doi: 10.1016/j.cclet.2015.04.015 shu

Solvent free synthesis of trifluoromethyl tertiary alcohols by cross Aldol reaction

1.
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: Ke-Hu Wang, Yu-Lai Hu,
Received Date: 10 January 2015
Available Online: 24 March 2015
Fund Project: We are thankful for the financial support from the National Natural Science Foundation of China (No. 21262031) (No. 21262031)

Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved in the presence of common inorganic base by grinding method at ambient temperature to give β-trifluoromethyl-β-hydroxyl ketones in high yields (up to 95%).
- Cross Aldol reaction,
- Grinding,
- Solvent free,
- Trifluoromethyl tertiary alcohols
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沈阳化工大学材料科学与工程学院沈阳 110142