Citation: Sreekanth Thota, Srujana Vallala, Rajeshwar Yerra, Eliezer J. Barreiro. Design, synthesis, characterization, cytotoxic and structure activity relationships of novel Ru(II) complexes[J]. Chinese Chemical Letters, ;2015, 26(6): 721-726. doi: 10.1016/j.cclet.2015.03.011 shu

Design, synthesis, characterization, cytotoxic and structure activity relationships of novel Ru(II) complexes

a National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fundação Oswaldo Cruz, Ministério da Saúde, Av.
a National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fundação Oswaldo Cruz, Ministério da Saúde, Av. Brasil 4036, Prédio da Expansão, 88 Andar, Sala 814, Manguinhos, 21040-361 Rio de Janeiro, RJ, Brazil;
b S.
b S.R. College of Pharmacy, Department of Pharmaceutical Chemistry & Toxicology, Ananthasagar, Warangal, Telangana 506371, India;
3.
c Programa de Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Corresponding author: Sreekanth Thota,
Received Date: 12 December 2014
Available Online: 27 February 2015
Fund Project: Coordenaç (CNPq) Oswaldo Cruz Foundation (Fiocruz) (CAPES)Department of Science and Technology, New Delhi, India [No. SR/WOS-A/LS-562/2011) dated 27/03/2012]. (Fiocruz)

Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium(II) arene compounds bearing thiosemicarbazone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium(II) arene compounds has been evaluated in several cell lines (Molt 4/C₈, L1210, CEM, HL60 and BEL7402). Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC₅₀ in the sub-micromolar range.
- Cytotoxic,
- Ligand,
- Ruthenium compounds,
- Structure activity relationships
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