Citation: Ben-Quan Hu, Li-Xia Wang, Jun-Feng Xiang, Luo Yang, Ya-Lin Tang. Cu(II)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone[J]. Chinese Chemical Letters, ;2015, 26(3): 369-372. doi: 10.1016/j.cclet.2014.12.006 shu

Cu(II)-catalyzed domino reaction of 2-halobenzamide and arylmethanamine to construct 2-aryl quinazolinone

Ben-Quan Hu ^a,b ,
Li-Xia Wang ^a,, ,
Jun-Feng Xiang ^a ,
Luo Yang ^b ,
Ya-Lin Tang ^a,,

1.
a State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China;
2.
b Key Laboratory for Environmentally Friendly Chemistry and Application, Department of Chemistry, Xiangtan University, Hunan 411105, China

Corresponding author: Li-Xia Wang, Ya-Lin Tang,
Received Date: 10 October 2014
Available Online: 1 December 2014
Fund Project: The authors wish to thank the National Natural Science Foundation of China (Nos. 21302188, 81072576, 91027033) (Nos. 21302188, 81072576, 91027033)

A novel method for achieving a copper(II)-catalyzed domino reaction for the construction of 2-aryl quinazolinones, without the addition of any ligand and additive, has been developed. The domino reaction achieved N-(α-substituted)benzylation, benzylic C-H amidation, and C-C (or C-H) bond cleavage.
- Copper (II)-catalysis,
- Domino reaction,
- 2-Aryl quinazolinones,
- C-C Bond cleavage,
- C-H bond cleavage
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