Citation: Ze-Shen Gao, Sheng Sun, Wei Li, Qing Ma, Qing Li, Zhong-Jun Li. An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide[J]. Chinese Chemical Letters, ;2014, 25(12): 1525-1530. doi: 10.1016/j.cclet.2014.09.016 shu

An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide

1.
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Corresponding author: Qing Li, Zhong-Jun Li,
Received Date: 11 June 2014
Available Online: 1 September 2014
Fund Project: This research was supported by the National Basic Research Program of China (973 Program, No. 2012CB822100) (973 Program, No. 2012CB822100) the National Key Technology R&D Program “New Drug Innovation” of China (No. 2012ZX09502001-001) (No. 2012ZX09502001-001)the National Natural Science Foundation of China (Nos. 91213301, 21232002). (Nos. 91213301, 21232002)

We utilized the glycosyl acceptor tagging method with ionic liquid support for synthesis of the core segment of Clostridium botulinum C2 toxin ligand through a divergent synthetic strategy without chromatographic purification. The total yield was 57.1% and the reaction was completed in 10 h. The efficient ionic liquid supported glycosylation and purification procedure was applied for the synthesis of branched glucosamine-containing oligosaccharides for the first time, which expanded the scope of ionic liquid supported synthesis of biologically important oligosaccharides.
- Ionic liquid,
- Oligosaccharide,
- Rapid assembling
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沈阳化工大学材料科学与工程学院沈阳 110142