Citation: Wen-Dong Xu, Ye Tian, Qing-Lan Guo, Yong-Chun Yang, Jian-Gong Shi. Secoeuphoractin, a minor diterpenoid with a new skeleton from Euphorbia micractina[J]. Chinese Chemical Letters, ;2014, 25(12): 1531-1534. doi: 10.1016/j.cclet.2014.09.012 shu

Secoeuphoractin, a minor diterpenoid with a new skeleton from Euphorbia micractina

1.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Jian-Gong Shi,
Received Date: 9 August 2014
Available Online: 4 September 2014
Fund Project:

A minor diterpenoid with a novel carbon skeleton, secoeuphoractin (1), was isolated from an ethanol extract of the roots of Euphorbia micractina. Its structure including the absolute configuration was determined by extensive spectroscopic studies, especially by 2D NMR and CD data analysis, in combination with a plausible biosynthetic pathway associated with co-occurring diverse diterpenoids. This compound showed activity against HIV-1 replication with an IC₅₀ value of 1.76±0.61 mmol/L.
- Euphorbia micractina,
- Euphorbiaceae,
- Diterpenoid,
- Secoeuphoractin
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