Citation: Jayant Sindhu, Harjinder Singh, J. M. Khurana, Chetan Sharma, K. R. Aneja. Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation[J]. Chinese Chemical Letters, ;2015, 26(1): 50-54. doi: 10.1016/j.cclet.2014.09.006 shu

Multicomponent domino process for the synthesis of some novel 5-(arylidene)-3-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-thiazolidine-2,4-diones using PEG-400 as an efficient reaction medium and their antimicrobial evaluation

1.
a Department of Chemistry, Delhi University, Delhi 110007, India;
2.
b Department of Microbiology, Kurukshetra University, Kurukshetra, India

Corresponding author: J. M. Khurana,
Received Date: 16 May 2014
Available Online: 29 August 2014

A series of novel thiazolidinedione-triazole hybrids were synthesized by one pot reaction between thiazolidine-2,4-dione, substituted aryl aldehydes, propargyl bromide and substituted aryl azides using piperidine, CuSO₄·5H₂O and sodium ascorbate as catalysts in PEG-400 as a highly efficient and green media. These thiazolidinedione-triazole hybrids were subjected to in vitro antibacterial activity against four strains namely, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against two fungal strains namely, Aspergillus niger and Aspergillus flavus.
- Multicomponent,
- Antibacterial,
- Antifungal,
- 1,2,3-Triazoles thiazolidine-2,4-diones
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