Citation: Ayekpam Bimolini Devi, Dinesh Singh Moirangthem, Narayan Chandra Talukdar, M. Damayanti Devi, N. Rajen Singh, Meitram Niraj Luwang. Novel synthesis and characterization of CuO nanomaterials: Biological applications[J]. Chinese Chemical Letters, ;2014, 25(12): 1615-1619. doi: 10.1016/j.cclet.2014.07.014 shu

Novel synthesis and characterization of CuO nanomaterials: Biological applications

a.
a. Department of Chemistry, Manipur University, Imphal 795001, India;
b.
b. Institute of Bioresources and Sustainable Development, Department of Biotechnology, Imphal 795001, India;
c.
c. Department of Life Sciences, Manipur University, Imphal 795003, India;
d.
d. Chemical Engineering and Process Development, National Chemical Laboratory, Pune 411008, India

Corresponding author: Meitram Niraj Luwang,
Received Date: 10 April 2014
Available Online: 14 July 2014

CuO nanoparticles were synthesized at a relatively low temperature (80 ℃) for 2 h using polyethylene glycol-glycerol mixture which acts as a capping agent. A detailed characterization of the synthesized nanomaterials were performed utilizing X-ray diffraction (XRD), infra-red spectroscopy (IR), thermogravimetric analysis (TGA-DTA), transmission electron microscopy (TEM), photoluminescence (PL) by studying its crystalline phase, vibrational mode, thermal analysis, morphology and photoluminescence properties. The effect of annealing on the as-prepared nanoparticles were studied and compared with their corresponding bulk counterpart. The synthesized nanoparticles have been screened for in vitro cytotoxicity (IC₅₀) studies against the human cervical adenocarcinoma cell line (HeLa) using MTT assay methods. The as-prepared nanoparticle inhibits the proliferation of this HeLa cell. The standard disc diffusion method has been used to study the antibacterial activity of the samples against the human pathogenic bacteria Escherichia coli (MTCC 729), Proteus mirabilis (MTCC 425) and Klebsiella pneumoniae subsp. pneumoniae (MTCC 432). The results have been compared with the positive control antibiotic gentamycin. The synthesized nanoparticles would provide a potential alternative to antibiotics for controlling some of the microorganisms causing urolithiasis.
- CuO nanoparticles,
- Annealing,
- HeLa cell lines,
- Cytotoxicity,
- Antibacterials
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沈阳化工大学材料科学与工程学院沈阳 110142