Citation: Ya-Qiong Li, Yun-Bin Chen, Zhi-Zhen Huang. Direct N-alkylation of amines with alcohols using AlC_l3 as a Lewis acid[J]. Chinese Chemical Letters, ;2014, 25(12): 1540-1544. doi: 10.1016/j.cclet.2014.07.006 shu

Direct N-alkylation of amines with alcohols using AlC_l3 as a Lewis acid

a.
a. Department of Chemistry, Zhejiang University, Hangzhou 310028, China;
b.
b. Zhejiang Jianye Chemical Co., Ltd., Hangzhou 311604, China;
c.
c. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Corresponding author: Zhi-Zhen Huang,
Received Date: 4 May 2014
Available Online: 27 June 2014
Fund Project: Financial supports from MOST of China (973 program, No. 2011CB808600) (973 program, No. 2011CB808600)

A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlC_l3 without any ligand or additive. Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlC_l3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields.
- Amine,
- Alcohol,
- N-Alkylated amine,
- Lewis acid,
- Synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142

Direct N-alkylation of amines with alcohols using AlCl3 as a Lewis acid

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通讯作者: 陈斌, bchen63@163.com

Direct N-alkylation of amines with alcohols using AlC_l3 as a Lewis acid