Citation: Hu-Yan Li, He Li, Bing-Jie Wang, Qun Gu, Zhi-Qiang Jiang, Xue-Dong Wu. Synthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitin nanocrystals composite scaffolds for tissue engineering[J]. Chinese Chemical Letters, ;2014, 25(12): 1635-1638. doi: 10.1016/j.cclet.2014.06.019 shu

Synthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitin nanocrystals composite scaffolds for tissue engineering

Hu-Yan Li ^a,b ,
He Li ^b ,
Bing-Jie Wang ^b ,
Qun Gu ^c,, ,
Zhi-Qiang Jiang ^c,, ,
Xue-Dong Wu ^b,,

a.
a. College of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, China;
b.
b. Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, Ningbo 315201, China;
c.
c. Ningbo University of Technology, Ningbo 315211, China

Corresponding author: Qun Gu, Zhi-Qiang Jiang, Xue-Dong Wu,
Received Date: 9 April 2014
Available Online: 6 June 2014
Fund Project: Ningbo Science Foundation (No. 2011A610116) (No. 1106) National Key Basic Research Program of China (973, No. 2014CB643305) (No. 2011A610116)the China Postdoctoral Science Foundation Funded Project (No. 2012T50564) for financial support. (973, No. 2014CB643305)

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitin nanocrystals (CNC) composite scaffolds were synthesized by the salt leaching and thermally induced phase separation (TIPS) technique. The scaffolds have porous structures with macro-pores (100-300 mm in diameters) and micro-pores (10 mm). The surface characteristics of the scaffolds were characterized by X-ray photoelectron spectroscopy (XPS) and static water contact angle measurement, and the mechanical properties were investigated by a compression test. Human adipose-derived stem cells (hADSCs) were seeded onto the PHBV/CNC scaffolds and in vitro cell culture results showed that the composite scaffolds enhanced the hADSCs adhesion, which implies that the material may have potential application in tissue engineering.
- PHBV,
- Chitin nanocrystals,
- Composite scaffolds,
- hADSCs
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