Citation: Qing-Han Li, Yong Ding, Neng-Wang Huang. Synthesis and biological activities of dithiocarbamates containing 1,2,3-triazoles group[J]. Chinese Chemical Letters, ;2014, 25(11): 1469-1472. doi: 10.1016/j.cclet.2014.05.022 shu

Synthesis and biological activities of dithiocarbamates containing 1,2,3-triazoles group

1.
College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China

Corresponding author: Qing-Han Li,
Received Date: 12 February 2014
Available Online: 30 April 2014
Fund Project: The authors are thankful to the National Centre for Drug Screening, Shanghai, China, for evaluating the inhibitory activity against CDC25B. We also thank the Fundamental Research Funds for the Central Universities, Southwest University for Nationalities (No. 12NZYTH03) (No. 12NZYTH03) the Natural Science Foundation of Southwest University for Nationalities (No. 381010) (No. 381010)

Twelve novel dithiocarbamates containing 1,2,3-trizaoles group were prepared via one step starting from organic halides, dithiocarbamic acid prop-2-ynyl ester, and sodium azide, using a very simple catalytic system composed of copper(Ⅰ) chloride and water at 70℃. The structures of the new compounds were characterized and screened for their in vitro anti-tumor. Four of the compounds displayed varying levels of anti-tumor activity against the CDC25B.
- Dithiocarbamates,
- 1,2,3-Trizaoles,
- Synthesis,
- Antitumor activity
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