Citation: Jian-Jun Li, Xing-Xing Gui. L-ProT catalyzed highly regioselective N-alkoxyalkylation of purine rings with vinyl ethers[J]. Chinese Chemical Letters, ;2014, 25(10): 1341-1345. doi: 10.1016/j.cclet.2014.04.023 shu

L-ProT catalyzed highly regioselective N-alkoxyalkylation of purine rings with vinyl ethers

Jian-Jun Li ^, ,
Xing-Xing Gui

1.
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China

Corresponding author: Jian-Jun Li,
Received Date: 17 February 2014
Available Online: 8 April 2014
Fund Project: We are grateful to the Natural Science Foundation of Zhejiang Province (No. LY13B020015) (No. LY13B020015)Zhejiang Key Innovation Team of Green Pharmaceutical Technology (No. 2012R10043-07) for financial support. (No. 2012R10043-07)

An efficient and regioselective synthesis of N-9 alkoxyalkylated purine nucleoside derivatives was achieved via the N-alkoxyalkylation of purine rings with vinyl ethers catalyzed by _L-ProT. The advantages of this protocol include good to excellent yield, mild reaction condition, and simple manipulation. A plausible mechanism for the transformation was given.
- L-Proline triflate,
- Regioselectivity,
- Purine,
- Vinyl ether,
- Addition reaction
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