Citation: Xiao-Qing Shan, Shu-Lin Peng, Hai-Li Shi, Xiao-Ling Wang, Li-Sheng Ding, Xun Liao. Panthogenins A and B, two novel norergostanol steroids from Dioscorea panthaica[J]. Chinese Chemical Letters, ;2014, 25(9): 1256-1258. doi: 10.1016/j.cclet.2014.04.004 shu

Panthogenins A and B, two novel norergostanol steroids from Dioscorea panthaica

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a Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;
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b Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041, China

Corresponding author: Xiao-Ling Wang, Xun Liao,
Received Date: 18 December 2013
Available Online: 21 March 2014
Fund Project:

Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes of Dioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.
- Dioscorea panthaica,
- Dioscoreaceae,
- Norergostanol steroids,
- Structural elucidation,
- Insulin sensitizing activity
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