Citation: Tariq Mahmood Babar, Muhammad Moazzam Naseer, Muhammad Khawar Rauf, Humayun Pervez, Masahiro Ebihara, Nasim Hasan Rama. Synthesis of hexacyclic fused isocoumarin framework through selective domino multicyclizations under catalyst and solvent free conditions[J]. Chinese Chemical Letters, ;2014, 25(9): 1282-1286. doi: 10.1016/j.cclet.2014.03.022 shu

Synthesis of hexacyclic fused isocoumarin framework through selective domino multicyclizations under catalyst and solvent free conditions

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a Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan;
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b Institute of Chemical Sciences, Organic Chemistry Division, Bahauddin Zakariya University, Multan 60800, Pakistan;
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c Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan

Corresponding author: Muhammad Moazzam Naseer, Nasim Hasan Rama,
Received Date: 15 January 2014
Available Online: 25 February 2014

A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200℃ under catalyst and solvent free reaction conditions. Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield. The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.
- Hexacyclic,
- Fused isocoumarin,
- One pot,
- Catalyst and solvent free
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