Citation: Xiu-Yun Sun, Yong-Hui Sun, Yu Rao. A gram-scale synthesis of multi-substituted arenes via palladium catalyzed C-H halogenation[J]. Chinese Chemical Letters, ;2014, 25(05): 667-669. doi: 10.1016/j.cclet.2014.03.021 shu

A gram-scale synthesis of multi-substituted arenes via palladium catalyzed C-H halogenation

1.
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China

Corresponding author: Yu Rao,
Received Date: 15 January 2014
Available Online: 27 February 2014
Fund Project: This work was supported by‘973' Project (No. 2011CB965300) (No. 2011CB965300) NSFC (Nos. 21142008, 21302106) (Nos. 21142008, 21302106)

(6-Amino-2-chloro-3-fluorophenyl)methanol is prepared through both traditional methods and palladium catalyzed iterative C-H halogenation reactions. In comparison to traditional approach, the C-H functionalization strategy demonstrated a few advantages including milder reaction conditions, higher yields, better selectivity and practicality, and high chemical diversity.
- Palladium catalysis,
- C-H halogenation,
- Substituted arenes
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沈阳化工大学材料科学与工程学院沈阳 110142