Citation: Min Jiang, Hai-Jun Yang, Yong Li, Zhi-Ying Jia, Hua Fu. Metal-free synthesis of substituted phenols from arylboronic acids in water at room temperature[J]. Chinese Chemical Letters, ;2014, 25(05): 715-719. doi: 10.1016/j.cclet.2014.03.018 shu

Metal-free synthesis of substituted phenols from arylboronic acids in water at room temperature

Min Jiang ^a ,
Hai-Jun Yang ^a,b,, ,
Yong Li ^a,b ,
Zhi-Ying Jia ^b ,
Hua Fu ^b

1.
a Beijing Key Laboratory for Analytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China;
2.
b Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: Hai-Jun Yang,
Received Date: 6 November 2013
Available Online: 20 February 2014
Fund Project: The authors thank the National Natural Science Foundation of China (No. 21105054) for financial support. (No. 21105054)

A convenient, efficient and practical metal-free method for the synthesis of substituted phenols from arylboronic acids has been developed. The protocol uses hydrogen peroxide as a hydroxylating agent, ammonium bicarbonate as an additive, and the reactions were conveniently performed in water at room temperature. Themethod shows an excellent tolerance of functional groups, so it will find a wide variety of applications in academic and industrial research.
- Arylboronic acids,
- Substituted phenols,
- Oxidative,
- Metal-free,
- Synthetic method
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