Citation: Hua Cheng, Qiong-You Wu, Fan Han, Guang-Fu Yang. Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction[J]. Chinese Chemical Letters, ;2014, 25(05): 705-709. doi: 10.1016/j.cclet.2014.03.013 shu

Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

1.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

Corresponding author: Qiong-You Wu, Guang-Fu Yang,
Received Date: 20 December 2013
Available Online: 21 February 2014
Fund Project:

Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds. In contrast to 3 or 5-aryl pyrazole, the preparation of 4-aryl pyrazole is fairly rare. Utilizing microwave irradiation, the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates. The remarkable advantages of this method are mild reaction conditions, simple operation, high yield, and short reaction time. Product structures were identified by MS, ¹H NMR, ¹³C NMR, and elemental analysis.
- 4-Aryl pyrazoles,
- Suzuki cross-coupling reactions,
- 4-Iodo-1-methyl-1H-pyrazole,
- Microwave irradiation
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沈阳化工大学材料科学与工程学院沈阳 110142