Citation: Zhi-Ke Liu, Da-Rong Wu, Yi-Ming Shi, Ting Zeng, Shao-Hua Liu, Xue Du, Yong-Jun Dang, Wei-Lie Xiao, Han-Dong Sun. Three new diterpenoids from Leonurus japonicus[J]. Chinese Chemical Letters, ;2014, 25(05): 677-679. doi: 10.1016/j.cclet.2014.01.047 shu

Three new diterpenoids from Leonurus japonicus

Zhi-Ke Liu ^a,c ,
Da-Rong Wu ^b ,
Yi-Ming Shi ^a,c ,
Ting Zeng ^d ,
Shao-Hua Liu ^b ,
Xue Du ^a ,
Yong-Jun Dang ^d,, ,
Wei-Lie Xiao ^a,, ,
Han-Dong Sun ^a

1.
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Chengdu No.
b Chengdu No. 1 Pharmaceutical Group Co., Ltd., Chengdu 610031, China;
3.
c University of Chinese Academy of Sciences, Beijing 100049, China;
4.
d Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China

Corresponding author: Yong-Jun Dang, Wei-Lie Xiao,
Received Date: 13 December 2013
Available Online: 21 January 2014
Fund Project: This project was supported financially by the Natural Science Foundation of Yunnan Province (No. 2012FB178) (No. 2012FB178)

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C₄-C₇ oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity.
- Leonurus japonicus,
- Leojaponin A,
- Leojaponin B,
- Leojaponin C
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