Citation: Hua-Yi Jiang, Wei-Guang Wang, Min Zhou, Hai-Yan Wu, Rui Zhan, Xue Du, Jian-Xin Pu, Han-Dong Sun. 6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity[J]. Chinese Chemical Letters, ;2014, 25(4): 541-544. doi: 10.1016/j.cclet.2014.01.041 shu

6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity

Hua-Yi Jiang ^a,b ,
Wei-Guang Wang ^a ,
Min Zhou ^a,b ,
Hai-Yan Wu ^a,b ,
Rui Zhan ^a ,
Xue Du ^a ,
Jian-Xin Pu ^a,, ,
Han-Dong Sun ^a,,

1.
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2.
b University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Jian-Xin Pu, Han-Dong Sun,
Received Date: 6 November 2013
Available Online: 15 January 2014

One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC₅₀ values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC₅₀ value of 3.3 μmol/L.
- Isodon sculponeatus,
- 6,7-seco-ent-Kaurane diterpenoid,
- Cytotoxicity,
- Anti-inflammatory activity
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