Citation: Peng Wang, Rui Zhang, Jin Cai, Jun-Qing Chen, Min Ji. Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes：Application to the synthesis of escitalopram[J]. Chinese Chemical Letters, ;2014, 25(4): 549-552. doi: 10.1016/j.cclet.2014.01.017 shu

Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes：Application to the synthesis of escitalopram

Peng Wang ^a ,
Rui Zhang ^b ,
Jin Cai ^b ,
Jun-Qing Chen ^b ,
Min Ji ^a,,

1.
a School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China;
2.
b School of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096, China

Corresponding author: Min Ji,
Received Date: 11 September 2013
Available Online: 17 December 2013
Fund Project: This work is supported by the National Basic Research Program of China (No. 2011CB933503) (No. 2011CB933503)

An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general strategy enables the synthesis of various substituted 1,3-dihydroisobenzofurans in high yields. Moreover, this method can be applied to efficiently synthesize escitalopram.
- Isobenzofuran,
- Salicylaldehyde,
- Efficient synthesis,
- Escitalopram
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