Citation: Davood Nematollahi, Saied Saeed Hosseiny Davarani, Pari Mirahmadpour, Fahimeh Varmaghani. A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance[J]. Chinese Chemical Letters, ;2014, 25(4): 593-595. doi: 10.1016/j.cclet.2014.01.005 shu

A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance

1.
a Faculty of Chemistry, Bu-Ali Sina University, Hamedan 65178-38683, Iran;
2.
b Department of Chemistry, Faculty of Science, University of Shahid Beheshti, Tehran 19835389, Iran;
3.
c Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran

Corresponding author: Davood Nematollahi,
Received Date: 29 July 2013
Available Online: 26 December 2013
Fund Project:

The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2,3-dihydrophthalazine-1,4-dione (1) in the presence of arylsulfinic acids (2a and 2b) as nucleophiles. The results show that, the electrogenerated phthalazine-1,4-dione (1ox) participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives. This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.
- 2,3-Dihydrophthalazine-1,4-dione,
- Cyclic voltammetry,
- Electrochemical synthesis,
- Sulfonamide,
- Arylsulfinic acid
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1.
沈阳化工大学材料科学与工程学院沈阳 110142