Citation: Srinivasa Rao Jetti, Anjna Bhatewara, Tanuja Kadre, Shubha Jain. Silica-bonded N-propyl sulfamic acid as an efficient recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under heterogeneous conditions[J]. Chinese Chemical Letters, ;2014, 25(3): 469-473. doi: 10.1016/j.cclet.2013.12.022 shu

Silica-bonded N-propyl sulfamic acid as an efficient recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under heterogeneous conditions

1.
Laboratory of Heterocycles, School of Studies in Chemistry & Biochemistry, Vikram University, Ujjain, Madhya Pradesh, 456010, India

Corresponding author: Srinivasa Rao Jetti,
Received Date: 14 October 2013
Available Online: 5 December 2013

Silica-bonded N-propyl sulfamic acid (SBNPSA) catalyzed one-pot three component Biginelli condensation of different substituted aromatic aldehydes with ethyl acetoacetate and urea/thoiurea to the respective 3,4-dihydropyrimidin-2-(1H)-ones and thiones in environment friendly procedure is described. The facile reaction conditions, simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
- Silica-bonded N-propyl sulfamic acid,
- 3,4-Dihydropyrimidin-2-(1H)-ones,
- Multi component reactions,
- Heterogeneous catalysis
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