Citation: Sangaraiah Nagarajan, Poovan Shanmugavelan, Murugan Sathishkumar, Ramasamy Selvi, Alagusundaram Ponnuswamy, Hariharan Harikrishnan, Vellasamy Shanmugaiah. An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents[J]. Chinese Chemical Letters, ;2014, 25(3): 419-422. doi: 10.1016/j.cclet.2013.12.017 shu

An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

1.
a Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, India;
2.
b Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India

Corresponding author: Alagusundaram Ponnuswamy, Vellasamy Shanmugaiah,
Received Date: 11 September 2013
Available Online: 10 December 2013

An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.
- Water promoted,
- Antibacterial,
- 1,2,3-Triazole,
- Pyrimidine
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