Citation: Qi Sun, Si Liu, Jian Sun, Shan-Shan Gong. An H-phosphonate strategy for the synthesis of 2’,3’-dideoxynucleoside triphosphates and homodinucleotides[J]. Chinese Chemical Letters, ;2014, 25(3): 427-430. doi: 10.1016/j.cclet.2013.11.029 shu

An H-phosphonate strategy for the synthesis of 2’,3’-dideoxynucleoside triphosphates and homodinucleotides

1.
Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China

Corresponding author: Qi Sun,
Received Date: 20 September 2013
Available Online: 14 November 2013
Fund Project: Project of the Science Funds of Jiangxi Education Office (No. GJJ12589) (No. 20114BAB203008) Key Project of Chinese Ministry of Education (No. 212092) (No. GJJ12589) and Scientific Research Foundation of Chinese Ministry of Human Resources and Social Security for Returned Chinese Scholars for financial support. (No. 212092)

The triphosphates and homodinucleotides of AZT and d4T have been efficiently synthesized from the corresponding nucleoside 5'-H-phosphonate monoesters via the reactive pyridinium phosphoramidate intermediates.
- 2’,3’-Dideoxynucleosides,
- Nucleoside triphosphate,
- Homodinucleotide,
- H-Phosphonate
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沈阳化工大学材料科学与工程学院沈阳 110142