Citation: Li Qiang Fu, Chen Yu Ling, Xing Sheng Guo, Hui Li He, Yu She Yang. Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain[J]. Chinese Chemical Letters, ;2012, 23(1): 9-12. doi: 10.1016/j.cclet.2011.10.002 shu

Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Received Date: 25 May 2011

Fund Project: We are grateful to National Science and Technology Major Project for the support of this research. The project described was supported by Key New Drug Creation and Manufacturing Program, China (No:2009ZX09301-001).

In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C(14) side chains were synthesized and evaluated for their in vitro antibacterial activities. The results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram-positive organisms. In particular, compound 10d exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid, emerged as potential molecule for further investigation.
- Synthesis,
- Pleuromutilin,
- Novel side chains,
- Antibacterial activity
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