Citation: Jiao Xia Sun, Yuan Liang Wang, Shu Hua Dou. A novel positively thermo-sensitive hydrogel based on ethylenediaminetetraacetic dianhydride and piperazine:Design, synthesis and characterization[J]. Chinese Chemical Letters, ;2012, 23(1): 97-100. doi: 10.1016/j.cclet.2011.09.023 shu

A novel positively thermo-sensitive hydrogel based on ethylenediaminetetraacetic dianhydride and piperazine:Design, synthesis and characterization

Key Lab of Biorheological Science and Technology, Ministry of Education, Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University, Chongqing 400030, China

Received Date: 2 June 2011

Fund Project: This study was supported by the National Natural Science Foundation of China (No. 30870609).

A new positively thermo-sensitive hydrogel was designed and synthesized by a condensation polymerization reaction of ethylenediaminetetraacetic dianhydride (EDTAD) and piperazine (PA) to give poly (ethylenediaminetetraacetic dianhydride-co-piperazine) (PEP). The obtained polymers' structure was characterized by FTIR and ¹³C NMR. The backbone of the polymer linked by amide bond and abundant of carboxyl groups as pendant group could form strong intermolecular and intramolecular hydrogen bond at lower temperature and dissociate at higher temperature, resulting in the polymer with thermo-sensitivity. The aqueous solution of PEP at lower temperature (< 20℃) showed micro-gel formation and transformed to transparent solution at higher temperature (> 40℃). Transition temperature shifted to higher value with the increasing of concentration. The hydrogel exhibited reversible phase transition and the transmittance change was not weakened by multiple temperature changes.
- Positively thermo-sensitive hydrogel,
- Degradation,
- Ethylenediaminetetraacetic dianhydride,
- Piperazine
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