Citation: Wei Hong, James Dowden. Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases[J]. Chinese Chemical Letters, ;2011, 22(12): 1439-1442. doi: 10.1016/j.cclet.2011.09.007 shu

Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases

Wei Hong ^a, ,
James Dowden ^b

a School of Chemistry and Chemical Engineering, Beifang University of Nationalities, Yinchuan 750021, China;
b School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK

Received Date: 24 May 2011

Fund Project: This work was financially supported by the Medical Research Council Grant (No.G0700840) and the University of Nottingham (Studentship to Wei Hong).

Chemically modified cellular co-factors that provide function, such as immobilization or incorporation of fluorescent dyes, are valuable probes of biological activity. A convenient route to obtain S-adenosyl methionine (AdoMet) analogues modified at N-6 adenosine to feature a linker terminating in azide functionality is described herein. Subsequent decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltransferases, PRMTs.
- Protein arginine methyltransferases,
- S-Adenosyl methionine,
- Nucleosides
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