Citation: Davinder Kumar, Archana Kapoor, Ananda Thangadurai, Pradeep Kumar, Balasubramanian Narasimhan. Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides[J]. Chinese Chemical Letters, ;2011, 22(11): 1293-1296. doi: 10.1016/j.cclet.2011.06.014 shu

Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides

a Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India;
b Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengode 637 205, India;
c Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India

Received Date: 31 March 2011

A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides (1-20) was synthesized and tested for in vitro antimicrobial activity. The results of antimicrobial studies indicated that the compounds having dinitro, methoxy, hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones. The QSAR investigation indicated the importance of the topological parameter, third order molecular connectivity index (³χ) in describing the antimicrobial activity of synthesized hydrazides.
- Benzylidene hydrazides,
- Synthesis,
- Antimicrobial,
- mt-QSAR,
- LOO method
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