Citation: Amin Rostami, Ashkan Tavakoli. Sulfamic acid as a reusable and green catalyst for efficient and simple synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-ones in water or methanol[J]. Chinese Chemical Letters, ;2011, 22(11): 1317-1320. doi: 10.1016/j.cclet.2011.06.008
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A series of 2, 3-dihydroquinazolin-4(1H)-ones have been synthesized in good to excellent yields through direct cyclocondensa-tion of anthranilamide and aryl aldehydes or ketones in water or methanol under mild conditions. The reaction was efficiently promoted by 10 mol% sulfamic acid (SA, H2NSO3H) and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity.
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