Citation: Jian Gao, Yang Hui Guo, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. A novel and efficient route for the preparation of atorvastatin[J]. Chinese Chemical Letters, ;2011, 22(10): 1159-1162. doi: 10.1016/j.cclet.2011.04.016 shu

A novel and efficient route for the preparation of atorvastatin

a Department of Biochemical Engineering, Northeast Agricultural University, Harbin 150030, China;
b Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China

Received Date: 17 January 2011

Fund Project: We are grateful for the financial supports from the National Key Project for Basic Research (No.2010CB11261 02) and the Outstanding Youth Foundation of Heilongjiang Province (No.JC200706).

A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
- Atorvastatin,
- Horner-Wadsworth-Emmons reaction,
- Synthesis,
- Intermediate
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