Citation: Bin Wang, Jing Li, Wen Long Huang, Hui Bin Zhang, Hai Qian, Yong Tang Zheng. Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents[J]. Chinese Chemical Letters, ;2011, 22(7): 781-784. doi: 10.1016/j.cclet.2011.01.015 shu

Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents

a Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
b School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;
c Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

Received Date: 11 October 2010

Fund Project: The work was supported by the National Natural Science Fundation of China (No.30772647) and the special major science and technology project of "Creation of Major New Drugs" (No.2009ZX09102-033).

A series of Andro derivatives were described and evaluated for their anti-HIV activity in vitro. Compound 10 and 16b, of which TI were > 10, had some anti-HTV-1 activity in vitro. Therein, compound 10 which was the best potent compound, could serve as a new lead for further development of anti-AIDS agents.
- Andrographolide,
- Anti-HIV,
- Derivatives,
- Natural products,
- Synthesis
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