Citation: Wei Huang, Ming Lv, Zhong Gao Gao. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery[J]. Chinese Chemical Letters, ;2011, 22(6): 749-752. doi: 10.1016/j.cclet.2010.12.057 shu

Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received Date: 8 November 2010

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No.30873168)

Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine(PEI)to synthesize copolymers mPEG-PCL-g-PEI with low cytotoxicity.The mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta potential.These nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene, which suggested that mPEG-PCL-g-PEl could serve as a highly efficient vector for siRNA delivery.
- Copolymers,
- Nanoparticles,
- Vector,
- Synthesis
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