Citation: Amir Khojastehnezhad, Farid Moeinpour, Abolghasem Davoodnia. PPA-SiO₂ catalyzed efficient synthesis of polyhydroquinoline derivatives through Hantzsch multicomponent condensation under solvent-free conditions[J]. Chinese Chemical Letters, ;2011, 22(7): 807-810. doi: 10.1016/j.cclet.2010.12.051 shu

PPA-SiO₂ catalyzed efficient synthesis of polyhydroquinoline derivatives through Hantzsch multicomponent condensation under solvent-free conditions

a Department of Chemistry, Faculty of Sciences, Islamic Azad University, Mashhad Branch, Mashhad 91735-413, Iran;
b Department of Chemistry, Faculty of Sciences, Islamic Azad University, Bandar Abbas Branch, Iran

Received Date: 25 October 2010

Silica gel-supported polyphosphoric acid (PPA-SiO₂) was found to be an efficient catalyst for the one-pot four-component Hantzsch condensation reaction of aryl aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to afford the corresponding polyhydroquinoline derivatives in high yields. The main advantages of the present approach are short reaction times, clean reaction profiles, simple experimental and workup procedures.
- Multicomponent reaction,
- One-pot synthesis,
- Solvent-free,
- Polyhydroquinoline derivatives,
- Silica-supported polyphosphoric acid (PPA-SiO₂)
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