Citation: Jia Qing Cao, Yu Zhang, Jiong Mo Cui, Yu Qing Zhao. Two new cucurbitane triterpenoids from Momordica charantia L.[J]. Chinese Chemical Letters, ;2011, 22(5): 583-586. doi: 10.1016/j.cclet.2010.11.033 shu

Two new cucurbitane triterpenoids from Momordica charantia L.

a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
b Yanbian University Health Science Center, Yanbian University, Yanji 133000, China

Received Date: 31 August 2010

Fund Project: This work was financially supported by E&T Modern Center for Natural Products of Liaoning Province of China (No.2008402021).We are grateful to the Analytical Center of Shenyang Pharmaceutical University for identification of the measurements of NMR, IR, HR-TOF-MS

Two new cucurbitane-type triterpenoids,(23E)-5 β,19-epoxycucurbita-6,23,25-triene-3β-ol(1)and(19R, 23E)-5β,19-epoxy-19-ethoxycucurbita-6,23-diene-3 β,25-diol(2), together with three known compounds, have been isolated from the fruit of Momordica charantia L.Their structures were determined on the basis of spectral analysis.Their cytotoxic activity was tested on 5 cancer cell lines, MCF-7, HepG2, Dul45, Colon205 and HL-60 by MTT assay.Compounds 1, 3 and 4 showed weak cytotoxicity.
- Momordica charantia L.,
- Cucurbitane-type,
- Triterpenoid,
- Cytotoxicity
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