Citation: Hong Xia Hao, Hong Zhou, Jing Chang, Jun Zhu, Tian Xin Wei. Molecularly imprinted polymers for highly sensitive detection of morphine using surface plasmon resonance spectroscopy[J]. Chinese Chemical Letters, ;2011, 22(4): 477-480. doi: 10.1016/j.cclet.2010.11.004 shu

Molecularly imprinted polymers for highly sensitive detection of morphine using surface plasmon resonance spectroscopy

a Key Laboratory of Evidence Science (CUPL), Ministry of Education, Beijing 100088, China;
b Forensic Sciences Institute, Ministry of Public Security, Beijing 100038, China;
c Department of Science, Beijing Institute of Technology, Beijing 100081, China

Received Date: 24 June 2010

Fund Project: We are grateful to the Innovation Project of the Ministry of Public Security of the People's Republic of China (No. 2008YYCXGKXXS130), Academician Foundation of the Ministry of Public Security of the People's Republic of China (No. 2011-23210044) and the National Natural Science Foundation of China (No. 81001348) for their financial supports.

Molecular imprinting technology is applied in surface plasmon resonance spectroscopy for highly sensitive and selective detection of morphine (MO). As SPR-based sensor of MO, the preparation of molecular imprinted polymer is as follows:methacrylic acids (MAA), ethylene glycol dimethacrylate (EGDMA), azodiisobutyronitrile (AIBN) were used as functional monomer, cross-linker and initiator, respectively. The experiment results showed that morphine imprinted polymer had the performance of high sensitivity and specificity, i.e. the relative signal of SPR response was proportional to the concentration of morphine in acetonitrile in the range of 10^-9 mol/L to 10^-6mol/L (1 ppb-1 ppm) with LOD of 10^-10mol/L, and MO was distinguished from its analogs, such as codeine.
- Molecular imprinting technique(MIT),
- Surface plasmon resonance(SPR),
- Morphine,
- Toxicological analysis
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