Citation: Xiao Fang Tin, Zhi Li, Shuai Hua Zhang, Chun Xia Wu, Chun Wang, Zhi Wang. Determination of strychnine and brucine in traditional Chinese medicine preparations by capillary zone electrophoresis with micelle to solvent stacking[J]. Chinese Chemical Letters, ;2011, 22(3): 330-333. doi: 10.1016/j.cclet.2010.10.044 shu

Determination of strychnine and brucine in traditional Chinese medicine preparations by capillary zone electrophoresis with micelle to solvent stacking

College of Science, Agricultural University of Hebei, Baoding 071001, China

Received Date: 10 June 2010

Fund Project: This research was supported by the Natural Science Foundations of Hebei (No. B2010000657).

A novel micelle to solvent stacking on-line sample preconcentration technique in capillary zone electrophoresis (MSS-CZE) has been developed to determine the strychnine and brucine in traditional Chinese medicine preparations. The optimal running buffer was 30 mmol/L H₃PO₄ containing 20% acetonitrile at pH 4.0. The sample matrix was 8 mmol/L H₃PO₄ containing 5 mmol/L sodium dodecyl sulfate (SDS) at pH 3.0. The established MSS-CZE method afforded more than 50-fold improvements in concentration sensitivity compared with typical CZE-UVanalysis. The calibration curve was linear in the range from 0.2 to 15.0 μg/mL for both strychnine and brucine, with correlation coefficients of 0.9984 and 0.9976, respectively. The limits of detection (S/N=3:1) for strychnine and brucine were 0.02 and 0.05 μg/mL, respectively. The MSS-CZE method has been successfully applied to the analysis of strychnine and brucine in Chinese medicinal preparations.
- On-line sample preconcentration,
- Micelle to solvent stacking,
- Capillary zone electrophoresis,
- Strychnine,
- Brucine,
- Traditional Chinese medicine preparation
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