Citation: Shan Bao Yu, Hao Min Liu, Yu Luo, Wei Lu. Synthesis of the key intermediate of ramelteon[J]. Chinese Chemical Letters, ;2011, 22(3): 264-267. doi: 10.1016/j.cclet.2010.10.021 shu

Synthesis of the key intermediate of ramelteon

Shan Bao Yu ^a, ,
Hao Min Liu ^a ,
Yu Luo ^a ,
Wei Lu ^b

a Department of Chemistry, East China Normal University, Shanghai 200062, China;
b Institute of Drug Discovery and Development, East China Normal University, Shanghai 200062, China

Received Date: 16 July 2010

Fund Project: We gratefully acknowledge the Shanghai Municipal Natural Science Foundation (No. 10ZR1409600). We also thank Lab of Organic Functional Molecules, the Sino-French Institute of ECNU for supports.

Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me₂S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.
- Ramelteon,
- Asymmetric Michael addition,
- Synthesis
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