Citation: Chang Qi Zhao, Yan Yan Zhu, Shu Ying Chen, Yukio Ogihara. Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity[J]. Chinese Chemical Letters, ;2011, 22(2): 181-184. doi: 10.1016/j.cclet.2010.10.013 shu

Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity

a Beijing Key Lab of Gene Engineering Drugs & Biological Technology, Key Lab for Cell Proliferation & Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China;
b Faculty of Agronome and Biotechnology, Yunnan Agriculture University, Kunming 650201, China;
c Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan

Received Date: 1 June 2010

Fund Project: This work was supported by the Chinese National Natural Science Foundation (No. 30973869), the Ministry of Science and Technology of China (No. 2008BAC39B05) and Foundation of Shannxi Provincial Education Department. We are really grateful to Miss. S. Kato and Miss. K. Takahashi providing the NMR and MS data.

A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi. On the basis of spectral evidences, its structure was established and named as 4,5-didemethylpodophyllotoxin 7'-O-β-D-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines (Hela, K562, SH-SY5Y and CNE) in vitro.
- Sinopodophyllum emodi,
- Berberidaceae,
- 4,5-Didemethylpodophyllotoxin 7'-O-β-D-glucopyranoside,
- Cytotoxicity
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