Citation: Tian Lan, Xian Xia Yuan, Jiang Hong Yu, Chao Jia, Yu Shi Wang, Hui Juan Zhang, Zi Feng Ma, Wei Dong Ye. Synthesis of mono-substituted derivatives of 6-aminoquinoline[J]. Chinese Chemical Letters, ;2011, 22(3): 253-255. doi: 10.1016/j.cclet.2010.10.005 shu

Synthesis of mono-substituted derivatives of 6-aminoquinoline

a School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, China;
b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
c Xinchang Pharmaceutical Factory, Zhejiang Pharmaceutics Co. Ltd., Xinchang 312500, China

Received Date: 17 June 2010

Fund Project: The authors are grateful for the financial support of this work by the National Science Foundation of China (No. 20776085), the 973 Program of China (No. 2007CB209700), the STCSM of China (Nos. 10JC1406900 and 09XD1402400), the Foundation of Zhejiang Pharmaceutics Co. Ltd. and the Opening Foundation of Zhejiang Provincial Top Key Discipline.

Several 6-aminoquinoline derivatives, which could be used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction. The nitro group was reduced effectively by SnCl₂ with no halo-removed occurred.
- 6-Aminoquinoline,
- 6-Nitroquinoline,
- Skraup reaction,
- Oxidant
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