Citation: Di Feng Wu, Mei Jia Yang, Yang Wang, Guo Wei Gao, Jian Men. A facile and efficient synthetic method for 4-phenylethynylphthalic anhydride[J]. Chinese Chemical Letters, ;2011, 22(2): 159-162. doi: 10.1016/j.cclet.2010.10.002 shu

A facile and efficient synthetic method for 4-phenylethynylphthalic anhydride

College of Chemistry, Sichuan University, Chengdu 610064, China

Received Date: 13 May 2010

Fund Project: The authors are grateful to the National Undergraduates’ Innovative Experiment Project of China and the Undergraduates’ Innovative Experiment Project of Sichuan University for financial support.

A novel approach to the synthesis of 4-phenylethynylphthalic anhydride has been described. The target compound was synthesized by Pd/Cu catalyzed Sonogashira coupling reaction between phenylacetylene and 4-bromophthalic acid which was for the first time employed as start material, followed by dehydration of 4-phenylethynylphthalic acid. Compared with traditional synthetic routes, this method provides several advantages such as readily available raw materials, convenient manipulation and high yield. The products were characterized by IR, ¹H NMR, ¹³C NMR, MS and elemental analysis, respectively.
- 4-Bromophthalic acid,
- 4-Phenylethynylphthalic anhydride,
- Pd/Cu catalyzed,
- Sonogashira coupling reaction
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