Citation: Keyume Ablajan, Hainimu Xiamuxi. The convenient synthesis of 4-arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones[J]. Chinese Chemical Letters, ;2011, 22(2): 151-154. doi: 10.1016/j.cclet.2010.09.023 shu

The convenient synthesis of 4-arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones

College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China

Received Date: 7 May 2010

Fund Project: We are grateful to the Natural Science Foundation of Xinjiang Science Technology Agency (No. 2009211A02) for the support.

4-Arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones were synthesized by the convenient three-component reaction of ethyl benzoylacetate, hydroxylamine and aromatic aldehydes in the presence of pyridine. The target compounds were also obtained by the reaction between 3-phenylisoxazol-5-one and aromatic aldehydes at 105℃ under solvent free condition. Yields of products depended considerably on the aldehyde used.
- Isoxazole,
- One-pot synthesis,
- Three-component reaction
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