Citation: Xiang Liu, Hai Bo Chen, Zheng Guang Pan, Jian He Xu, He Xing Li. Microwave-assisted synthesis of α-hydroxy aromatic ketones from α-bromo aromatic ketones in water[J]. Chinese Chemical Letters, ;2011, 22(1): 53-56. doi: 10.1016/j.cclet.2010.07.027 shu

Microwave-assisted synthesis of α-hydroxy aromatic ketones from α-bromo aromatic ketones in water

a School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China;
b State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;
c Department of Chemistry, Shanghai Normal University, Shanghai 200234, China

Received Date: 14 May 2010

Fund Project: This research was financially supported by the National Special Fund for State Key Laboratory of Bioreactor Engineering (No.2060204) and the National Natural Science Foundation of China (No.20672037).

A reaction of α-bromo aromatic ketones in water with microwave irradiation gave the corresponding α-hydroxy aromatic ketones in good yields.The use of microwaves was found to significantly improve yields and shorten the reaction time.This reaction afforded a very clean, convenient method for the synthesis of α-hydroxy aromatic ketones.
- α-Hydroxy aromatic ketones,
- α-Bromo aromatic ketones,
- Microwave irradiation
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