Citation: Jin Hao Zhao, Ming Hua Ji, Xu Hui Xu, Jing Li Cheng, Guo Nian Zhu. Synthesis analogues of milbemycin and their bioactivity evaluation[J]. Chinese Chemical Letters, ;2010, 21(12): 1391-1394. doi: 10.1016/j.cclet.2010.06.035 shu

Synthesis analogues of milbemycin and their bioactivity evaluation

a College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China;
b Zhejiang NHU Ltd., Shaoxing 312500, China

Received Date: 12 April 2010

Fund Project: This work is financially supported by National Natural Science Foundation of China (No.30700532) and the Science and Technology Project of Zhejiang province (No.2008C02007-3).

Eight new 13-O-aminocarbonylivermectin aglycones and 4'-O-aminocarbonylivermectin monosaccharide were synthesized from ivermectin aglycone and ivermectin monosaccharide by the selective protection of C₅-OH group. Their bioactivities were evaluated against spicier mites (Tetranychus cinnabarinus), aphid (Aphis fabae) and orlental armyworm (Mythimma sepatara). Their structures were confirmed by ¹H NMR. MS.
- 13-O-Aminocarbonylivermectin aglycone,
- 4'-O-Aminocarbonylivermectin monosaccharide,
- Synthesis,
- Insecticidal and acaricidal activities
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