Citation: Vanga Malla Reddy, Kunduru Ravinder Reddy. Synthesis and biological evaluation of some novel-3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines[J]. Chinese Chemical Letters, ;2010, 21(10): 1145-1148. doi: 10.1016/j.cclet.2010.06.017 shu

Synthesis and biological evaluation of some novel-3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines

Dr. Ch. Ravishanker Memorial Medicinal Chemistry Research Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India

Received Date: 28 December 2009

Fund Project: The authors are thankful to the authorities of Kakatiya University,Warangal,AP (India) for the facilities and encouragement.

The synthesis of a new series of 3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines (6a-h) was achieved in excellent yields by the condensation of 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones (5a-h) with hydroxylamine at room temperature. These 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones (5a-h) were obtained by the condensation of 2-acetyl benzimidazoles (4a-d) with different aromatic aldehydes, which in turn were obtained by the oxidation of 2-(α-hydroxy)ethyl benzimidazoles (3a-d) prepared by the reaction of o-phenylenediamines (1a-d) with α-hydroxy propionic acid 2. The synthesized compounds were characterized by their IR, ¹H NMR and MS analyses. These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.
- Benzimidazolyl-5-arylisoxazolines,
- Antibacterial,
- Antifungal activity
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