Citation: Zahed Karimi-Jaberi, Mohammad Barekat. One-pot synthesis of tri-and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions[J]. Chinese Chemical Letters, ;2010, 21(10): 1183-1186. doi: 10.1016/j.cclet.2010.06.012 shu

One-pot synthesis of tri-and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions

Zahed Karimi-Jaberi ^a, ,
Mohammad Barekat ^b

Department of Chemistry, Islamic Azad University, Firoozabad Branch, P. O. Box 74715-117, Firoozabad, Fars, Iran

Received Date: 24 February 2010

Sodium dihydrogen phosphate (NaH₂PO₄) efficiently catalyzes the condensation reaction of benzil, aldehydes, amines and ammonium acetate in a four-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding tetra-substituted imidazoles in high yields. Also an efficient route was developed for the synthesis of tri-substituted imidazoles from condensation of benzil, aldehydes and ammonium acetate using NaH₂PO₄.
- Sodium dihydrogen phosphate,
- Imidazoles,
- Benzii,
- Solvent-free
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