Citation: Xin Ying Zhang, Ying Ying Qu, Xue Sen Fan. An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions[J]. Chinese Chemical Letters, ;2010, 21(10): 1191-1194. doi: 10.1016/j.cclet.2010.04.037 shu

An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions

School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China

Received Date: 25 February 2010

Fund Project: We are grateful to the National Natural Science Foundation of China (Nos.20772025 and 20972042),the Program for Science&Technology Innovation Talents in Universities of Henan Province (No.2008HASTIT006),Innovation Scientists and Technicians Troop Construction Projects of Henan Province (No.104100510019) and the Natural Science Foundation of Henan Province (Nos.092300410192 and 094300510054).

An environmentally benign and highly efficient one-pot preparation of α-aminophosphonates under solvent-free conditions was developed. By employing this method, 5-aminophosphonate substituted pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline and dimethylphosphite.
- Aminophosphonate,
- 5-Substituted pyrimidine nucleoside,
- Solvent-free reaction,
- Green synthesis
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