Citation: Chun Fen Xiao, Li Yang Tao, Hong Yi Sun, Wen Wei, Yu Chen, Li Wu Fu, Yong Zou. Design,synthesis and antitumor activity of a series of novel coumarin-stilbenes hybrids,the 3-arylcoumarins[J]. Chinese Chemical Letters, ;2010, 21(11): 1295-1298. doi: 10.1016/j.cclet.2010.04.034 shu

Design,synthesis and antitumor activity of a series of novel coumarin-stilbenes hybrids,the 3-arylcoumarins

Chun Fen Xiao ^a,b, ,
Li Yang Tao ^c ,
Hong Yi Sun ^a,b ,
Wen Wei ^a ,
Yu Chen ^a,b ,
Li Wu Fu ^c ,
Yong Zou ^a

a Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, China;
b Graduated School of Chinese Academy of Sciences, Beijing 100049, China;
c Oncology Research Department of Sun Yat-Sen University Cancer Center, Guangzhou 510060, China

Received Date: 9 March 2010

Fund Project: We thank the National Key Technology R&D Program, Science and Technology Program of Guangdong Province and Strategic Cooperation Program between Guangdong Province and Chinese Academy of Sciences, PR China (Nos.2007BAD82B02, 2006B35604002, and 2009B091300125) for financial support.

A series of novel coumarin-stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents. The results showed that some compounds exhibited in vitro activity against KB, KV, MCF-7, MCF-7/ADR cell lines to some extent. Compound 3a showed remarkable effect against KB tumor cells with an IC₅₀ value of 5.18 μmol/L.
- Perkin reaction,
- 3-Arylcoumarin,
- Trans-stilbene,
- Antitumor activity
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